ID | 110710 |
著者 |
カジモト, カズアキ
Institute for Genome Research, The University of Tokushima
片岡, 正俊
Institute for Genome Research, The University of Tokushima
寺田, 弘
Faculty of Pharmaceutical Sciences, Tokyo University of Science
篠原, 康雄
Institute for Genome Research, The University of Tokushima|Faculty of Pharmaceutical Sciences, The University of Tokushima|Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)
徳島大学 教育研究者総覧
KAKEN研究者をさがす
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キーワード | brown adipose tissue
mitochondria
energy metabolism
uncoupling
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資料タイプ |
学術雑誌論文
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抄録 | Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT.
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掲載誌名 |
The journal of medical investigation : JMI
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ISSN | 13431420
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cat書誌ID | AA11166929
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巻 | 51
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号 | 1-2
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開始ページ | 20
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終了ページ | 28
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並び順 | 20
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発行日 | 2004-02
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
薬学系
先端酵素学研究所
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