ID 110710
Author
Kajimoto, Kazuaki Institute for Genome Research, The University of Tokushima
Yamazaki, Naoshi Faculty of Pharmaceutical Sciences, The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kataoka, Masatoshi Institute for Genome Research, The University of Tokushima
Terada, Hiroshi Faculty of Pharmaceutical Sciences, Tokyo University of Science
Shinohara, Yasuo Institute for Genome Research, The University of Tokushima|Faculty of Pharmaceutical Sciences, The University of Tokushima|Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology (AIST) Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
brown adipose tissue
mitochondria
energy metabolism
uncoupling
Content Type
Journal Article
Description
Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
51
Issue
1-2
Start Page
20
End Page
28
Sort Key
20
Published Date
2004-02
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences
Institute of Advanced Medical Sciences