| ID | 111875 |
| Author |
Sawada, Jun-ichi
University of Shizuoka
Osawa, Ayumi
The University of Tokushima|Hokkaido University
Takeuchi, Tomoki
Kyoto University
Kaneda, Masato
Kyoto University
Oishi, Shinya
Kyoto University
Fujii, Nobutaka
Kyoto University
Asai, Akira
University of Shizuoka
Tanino, Keiji
Hokkaido University
Namba, Kosuke
The University of Tokushima|Hokkaido University
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| Keywords | kinesin spindle protein
KSP
probe
triazapentalene
|
| Content Type |
Journal Article
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| Description | 1,3a,6a-Triazapentalene is a compact fluorescent chromophore. In this study, triazapentalene was used to modify a series of biphenyl-type inhibitors of kinesin spindle protein (KSP) to develop fluorescent probes for the intracellular visualization of this protein. Microscopic studies demonstrated that these novel triazapentalene-labeled compounds exhibited inhibitory activity towards KSP in cultured cells and provided important information concerning the intracellular distribution.
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| Journal Title |
Bioorganic & Medicinal Chemistry Letters
|
| ISSN | 0960894X
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| NCID | AA11522706
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| Publisher | Elsevier
|
| Volume | 26
|
| Issue | 23
|
| Start Page | 5765
|
| End Page | 5769
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| Published Date | 2016-10-15
|
| Rights | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Author
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| departments |
Pharmaceutical Sciences
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