| ID | 111875 |
| 著者 |
Sawada, Jun-ichi
University of Shizuoka
Osawa, Ayumi
The University of Tokushima|Hokkaido University
Takeuchi, Tomoki
Kyoto University
Kaneda, Masato
Kyoto University
Oishi, Shinya
Kyoto University
Fujii, Nobutaka
Kyoto University
Asai, Akira
University of Shizuoka
Tanino, Keiji
Hokkaido University
|
| キーワード | kinesin spindle protein
KSP
probe
triazapentalene
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | 1,3a,6a-Triazapentalene is a compact fluorescent chromophore. In this study, triazapentalene was used to modify a series of biphenyl-type inhibitors of kinesin spindle protein (KSP) to develop fluorescent probes for the intracellular visualization of this protein. Microscopic studies demonstrated that these novel triazapentalene-labeled compounds exhibited inhibitory activity towards KSP in cultured cells and provided important information concerning the intracellular distribution.
|
| 掲載誌名 |
Bioorganic & Medicinal Chemistry Letters
|
| ISSN | 0960894X
|
| cat書誌ID | AA11522706
|
| 出版者 | Elsevier
|
| 巻 | 26
|
| 号 | 23
|
| 開始ページ | 5765
|
| 終了ページ | 5769
|
| 発行日 | 2016-10-15
|
| 権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
著者版
|
| 部局 |
薬学系
|
