ID 111875
Author
Sawada, Jun-ichi University of Shizuoka
Osawa, Ayumi The University of Tokushima|Hokkaido University
Takeuchi, Tomoki Kyoto University
Kaneda, Masato Kyoto University
Oishi, Shinya Kyoto University
Fujii, Nobutaka Kyoto University
Asai, Akira University of Shizuoka
Tanino, Keiji Hokkaido University
Keywords
kinesin spindle protein
KSP
probe
triazapentalene
Content Type
Journal Article
Description
1,3a,6a-Triazapentalene is a compact fluorescent chromophore. In this study, triazapentalene was used to modify a series of biphenyl-type inhibitors of kinesin spindle protein (KSP) to develop fluorescent probes for the intracellular visualization of this protein. Microscopic studies demonstrated that these novel triazapentalene-labeled compounds exhibited inhibitory activity towards KSP in cultured cells and provided important information concerning the intracellular distribution.
Journal Title
Bioorganic & Medicinal Chemistry Letters
ISSN
0960894X
NCID
AA11522706
Publisher
Elsevier
Volume
26
Issue
23
Start Page
5765
End Page
5769
Published Date
2016-10-15
Rights
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences