ID | 113033 |
Title Alternative | RV Stiffness and Relaxation in PAH
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Author |
Hayabuchi, Yasunobu
Tokushima University
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Ono, Akemi
Tokushima University
Kagami, Shoji
Tokushima University
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Keywords | diastolic function
diastolic heart failure
pulmonary hypertension
relaxation
right ventricle
right ventricular function
right ventricular pressure overload
stiffness
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Content Type |
Journal Article
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Description | Background
The rate of left ventricular pressure decrease during isovolumic relaxation is traditionally assessed algebraically via 2 empirical indices: the monoexponential and logistic time constants (τE and τL). Since the pattern of right ventricular (RV) pressure decrease is quite different from that of the left ventricular, we hypothesized that novel kinematic model parameters are more appropriate and useful to evaluate RV diastolic dysfunction. Methods and Results Eight patients with pulmonary arterial hypertension (age 12.5±4.8 years) and 20 normal subjects (control group; age 12.3±4.4 years) were enrolled. The kinematic model was parametrized by stiffness/restoring Ek and damping/relaxation μ. The model predicts isovolumic relaxation pressure as a function of time as the solution of d2P/dt2+(1/μ)dP/dt+EkP=0, based on the theory that the pressure decay is determined by the interplay of inertial, stiffness/restoring, and damping/relaxation forces. In the assessment of RV diastolic function, τE and τL did not show significant differences between the pulmonary arterial hypertension and control groups (46.8±15.5 ms versus 32.5±14.6 ms, and 19.6±5.9 ms versus 14.5±7.2 ms, respectively). The pulmonary arterial hypertension group had a significantly higher Ek than the control group (915.9±84.2 s−2 versus 487.0±99.6 s−2, P<0.0001) and a significantly lower μ than the control group (16.5±4.3 ms versus 41.1±10.4 ms, P<0.0001). These results show that the RV has higher stiffness/elastic recoil and lower cross‐bridge relaxation in pulmonary arterial hypertension. Conclusions The present findings indicate the feasibility and utility of kinematic model parameters for assessing RV diastolic function. |
Journal Title |
Journal of the American Heart Association
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ISSN | 20479980
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Publisher | The American Heart Association|Wiley
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Volume | 7
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Issue | 9
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Start Page | e008670
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Published Date | 2018-04-19
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Rights | © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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language |
eng
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departments |
Medical Sciences
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