ID 113033
タイトル別表記
RV Stiffness and Relaxation in PAH
著者
Ono, Akemi Tokushima University
Homma, Yukako Tokushima University
キーワード
diastolic function
diastolic heart failure
pulmonary hypertension
relaxation
right ventricle
right ventricular function
right ventricular pressure overload
stiffness
資料タイプ
学術雑誌論文
抄録
Background
The rate of left ventricular pressure decrease during isovolumic relaxation is traditionally assessed algebraically via 2 empirical indices: the monoexponential and logistic time constants (τE and τL). Since the pattern of right ventricular (RV) pressure decrease is quite different from that of the left ventricular, we hypothesized that novel kinematic model parameters are more appropriate and useful to evaluate RV diastolic dysfunction.
Methods and Results
Eight patients with pulmonary arterial hypertension (age 12.5±4.8 years) and 20 normal subjects (control group; age 12.3±4.4 years) were enrolled. The kinematic model was parametrized by stiffness/restoring Ek and damping/relaxation μ. The model predicts isovolumic relaxation pressure as a function of time as the solution of d2P/dt2+(1/μ)dP/dt+EkP=0, based on the theory that the pressure decay is determined by the interplay of inertial, stiffness/restoring, and damping/relaxation forces. In the assessment of RV diastolic function, τE and τL did not show significant differences between the pulmonary arterial hypertension and control groups (46.8±15.5 ms versus 32.5±14.6 ms, and 19.6±5.9 ms versus 14.5±7.2 ms, respectively). The pulmonary arterial hypertension group had a significantly higher Ek than the control group (915.9±84.2 s−2 versus 487.0±99.6 s−2, P<0.0001) and a significantly lower μ than the control group (16.5±4.3 ms versus 41.1±10.4 ms, P<0.0001). These results show that the RV has higher stiffness/elastic recoil and lower cross‐bridge relaxation in pulmonary arterial hypertension.
Conclusions
The present findings indicate the feasibility and utility of kinematic model parameters for assessing RV diastolic function.
掲載誌名
Journal of the American Heart Association
ISSN
20479980
出版者
The American Heart Association|Wiley
7
9
開始ページ
e008670
発行日
2018-04-19
権利情報
© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EDB ID
338396
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系