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ID 114359
Title Alternative
Allele Loss in MEN 1-associated Pituitary Tumor
Author
Iwahana, Hiroyuki The University of Tokushima
Kubo, Katsuyuki The University of Tokushima
Saito, Shiro The University of Tokushima
Keywords
Allele loss
Chromosome 11
Pituitary tumor
Multiple endocrine neoplasia type 1
Content Type
Journal Article
Description
We have examined the allele loss of chromosome 11 in a pituitary tumor from a patient with familial multiple endocrine neoplasia type 1 (MEN 1). The extensive loss of chromosome 11, including loci of D11S149, HRAS1 and F2, was detected by the loss of heterozygosity. All of the lost alleles of these loci were transmitted from the unaffected father and not from an affected mother. This is the first evidence of allele loss of chromosome 11 in a pituitary tumor of MEN 1 and supports the idea that similar allelic deletion of MEN1 locus on chromosome 11 is the common genetic basis for tumorigenesis in the pituitary, endocrine pancreas, and parathyroid gland in MEN 1.
Journal Title
Japanese Journal of Cancer Research
NCID
AA00690844
Publisher
Japanese Cancer Association|John Wiley & Sons
Volume
82
Issue
8
Start Page
886
End Page
889
Published Date
1991-08
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences
Institute of Advanced Medical Sciences