ID | 114359 |
タイトル別表記 | Allele Loss in MEN 1-associated Pituitary Tumor
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著者 |
Iwahana, Hiroyuki
The University of Tokushima
Kubo, Katsuyuki
The University of Tokushima
齋藤, 史郎
The University of Tokushima
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キーワード | Allele loss
Chromosome 11
Pituitary tumor
Multiple endocrine neoplasia type 1
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資料タイプ |
学術雑誌論文
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抄録 | We have examined the allele loss of chromosome 11 in a pituitary tumor from a patient with familial multiple endocrine neoplasia type 1 (MEN 1). The extensive loss of chromosome 11, including loci of D11S149, HRAS1 and F2, was detected by the loss of heterozygosity. All of the lost alleles of these loci were transmitted from the unaffected father and not from an affected mother. This is the first evidence of allele loss of chromosome 11 in a pituitary tumor of MEN 1 and supports the idea that similar allelic deletion of MEN1 locus on chromosome 11 is the common genetic basis for tumorigenesis in the pituitary, endocrine pancreas, and parathyroid gland in MEN 1.
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掲載誌名 |
Japanese Journal of Cancer Research
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cat書誌ID | AA00690844
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出版者 | Japanese Cancer Association|John Wiley & Sons
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巻 | 82
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号 | 8
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開始ページ | 886
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終了ページ | 889
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発行日 | 1991-08
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
出版社版
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部局 |
歯学系
先端酵素学研究所
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