ID | 115280 |
Author | |
Keywords | Atherosclerotic cardiovascular disease
Low-density lipoprotein cholesterol
American College of Cardiology and American Heart Association
Lipid-lowering therapy
Statin-associated muscle symptoms
Statin intolerance
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Content Type |
Journal Article
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Description | Statins can decrease lowering level of Low-Density Lipoprotein Cholesterol (LDL-C), and have been effective for prevention of Atherosclerotic Cardiovascular Disease (ASCVD). Lipid-Lowering Therapy (LLT) has been prevalent, but some cases develop statin intolerance. Cases with statin intolerance may show Statin-Associated Muscle Symptoms (SAMS). SAMS includes various clinical manifestations, such as general malaise, mild weakness, muscle pain and cramps with about 5-10% of incidence in clinical practice. European Atherosclerosis Society (EAS) consensus panel included three SAMS types, which are myalgias, myositis and rhabdomyolysis. There is a proposal of algorithm for the management of SAMS with several stages such as genesis, exams, diagnosis, evaluation and management. As non-statin based therapies, ezetimibe and Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors can be added and applied.
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Journal Title |
Research and Case Reports on Clinical and Experimental Cardiology
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Publisher | Scholars Insight Publishers
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Volume | 1
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Issue | 1
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Start Page | 101
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Published Date | 2020-06-26
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Rights | This work is licensed under a Creative Commons Attribution 4.0 International License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted se, distribution, and reproduction in any medium, provided the original work is properly cited.
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FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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