ID | 116587 |
Author | |
Keywords | Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2i)
Cardiovascular Outcome Trials (CVOT)
Heart Failure with Reduced Ejection Fraction (HFrEF)
Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD)
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Content Type |
Journal Article
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Description | Sodium-glucose cotransporter-2 inhibitor (SGLT2i) was initially applied to diabetes, successively to heart failure and recently to chronic kidney disease (CKD) with its expanding application. For decades, several cardiovascular outcome trials (CVOT) have been conducted for SGLT2i. They include mega studies of CREDENCE, CANVAS, DECLARE-TIMI 58, EMPA-REG OUTCOME, EMPA-KIDNEY, EMPEROR-Reduced, DAPA-HF, DAPA-CKD, and others. DAPA-CKD is an on-going study for non-DM cases. Recommendations for actual medical practice of SGLT2i include i) careful combined treatment of diuretics, ii) checking urinary ketones against ketosis, iii) avoiding the first-line agent, and iv) establishing basically reasonable lifestyle and nutrition in addition to medical agents.
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Journal Title |
International Journal of Endocrinology and Diabetes
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ISSN | 26943875
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Publisher | Pubtexto Publishers
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Volume | 4
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Issue | 2
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Start Page | 121
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Published Date | 2021-10-17
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Rights | This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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DOI (Published Version) | |
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language |
eng
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Publisher
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departments |
Medical Sciences
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