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ID 116924
Author
Miki, K Hayashi Hospital
Bando, Hiroshi Hayashi Hospital|Tokushima University|Japan Low Carbohydrate Diet Promotion Association KAKEN Search Researchers
Hayashi, K Hayashi Hospital
Dohi, A Japan Low Carbohydrate Diet Promotion Association
Kamoto, A Hayashi Hospital
Keywords
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs)
Oral semaglutide (Rybelsus)
Sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC)
Fasting time period
Content Type
Journal Article
Description
Recent pharmacological topic for diabetes includes clinical application of Glucagon-like peptide 1 receptor agonists (GLP-1 RAs). Among them, oral semaglutide (Rybelsus) has been developed as the first oral form of GLP-1RA by useful application of sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). Semaglutide concentration in the blood was compared when fasting time period after Rybelsus administration would be 15, 30, 60 and 120 minutes. As a result, the concentration ratio after 4 hours was 1.00, 1.67, 2.60 and 3.06, respectively. Authors have experienced a diabetic case of remarkable efficacy as HbA1c -1.4% and weight -5kg, who kept 3-4 hours fasting after Rybelsus intake.
Journal Title
SunText Review of Medical & Clinical Research
ISSN
27664813
Publisher
SunText Reviews
Volume
3
Issue
1
Start Page
150
Published Date
2022-04-04
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences