Improved Glucose Variability of Continuous Glucose Monitoring (CGM) By Intake of Japanese Healthy Tofu as Low Carbohydrate Diet (LCD)

Background: Concerning Type 2 Diabetes (T2D), some recent clinical trends have been found such as evaluation method by continuous glucose monitoring (CGM) and nutritional therapy by low carbohydrate diet (LCD).
Case presentation: The case is 66-year-old men with T2D for 24 years duration. His diabetic control had been stable, but HbA1c was elevated to 8.1% in January 2022. He was advised to take Japanese healthy tofu instead of rice as LCD, and received CGM for totally 6 weeks. [Results] His daily profile of blood glucose was improved, and HbA1c decreased as 6.9%, 6.4%, 5.9% by estimated HbA1c calculated by FreeStyle Libre.
Discussion & conclusion: For actual LCD continuation, Morinaga silky tofu showed clinical effects. However, some discrepancy of HbA1c values between estimated HbA1c by CGM and out-clinic HbA1c by laboratory test would be present. Possible reasons include i) detection of glucose in every 7.5-15.0 min, ii) glucose level in the interstitial tissue. Such accumulated research data would be hopefully reference for future development.

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