ID | 118068 |
Author |
Koga, Takeru
Tokushima University
Ito, Hideyuki
Okayama Prefectural University
Iwaoka, Yuji
Okayama Prefectural University
Noshita, Toshiro
Prefectural University of Hiroshima|Gifu University of Medical Science
Tai, Akihiro
Prefectural University of Hiroshima|Tokushima University
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Keywords | Paeonia lactiflora
PC12 cells
NGF
isorhamnetin-3-O-glucoside
astragalin
neurite outgrowth-promoting activity
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Content Type |
Journal Article
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Description | Isorhamnetin-3-O-glucoside and astragalin, flavonol glucosides, were isolated from the petals of Paeonia lactiflora as neurite outgrowth-promoting compounds. Isoquercitrin, formed by demethylating the B ring of isorhamnetin-3-O-glucoside or by adding a hydroxyl group to the B ring of astragalin, was evaluated for neurite outgrowth-promoting activity and was compared with the activities of isorhamnetin-3-O-glucoside and astragalin. The activities of isorhamnetin, kaempferol, and quercetin, aglycones corresponding to isorhamnetin-3-O-glucoside, astragalin, and isoquercitrin, respectively, were also evaluated. Isorhamnetin-3-O-glucoside and astragalin showed much stronger neurite outgrowth-promoting activities than the activities of the other tested flavonoids. They exhibited relatively weak anti-oxidant activities and moderate AChE inhibitory activities compared to the activities of the other tested flavonoids. Isorhamnetin-3-O-glucoside and astragalin promoted morphological neurite outgrowth and the expression of neurofilaments induced by NGF in PC12 cells. Isorhamnetin-3-O-glucoside and astragalin might be candidate compounds as neural differentiation agents in peripheral nerves and functional food ingredients preventing cognitive decline.
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Journal Title |
Molecules
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ISSN | 14203049
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Publisher | MDPI
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Volume | 27
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Issue | 22
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Start Page | 7670
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Published Date | 2022-11-08
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Rights | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Bioscience and Bioindustry
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