ID | 118068 |
著者 |
Koga, Takeru
Tokushima University
Ito, Hideyuki
Okayama Prefectural University
Iwaoka, Yuji
Okayama Prefectural University
Noshita, Toshiro
Prefectural University of Hiroshima|Gifu University of Medical Science
|
キーワード | Paeonia lactiflora
PC12 cells
NGF
isorhamnetin-3-O-glucoside
astragalin
neurite outgrowth-promoting activity
|
資料タイプ |
学術雑誌論文
|
抄録 | Isorhamnetin-3-O-glucoside and astragalin, flavonol glucosides, were isolated from the petals of Paeonia lactiflora as neurite outgrowth-promoting compounds. Isoquercitrin, formed by demethylating the B ring of isorhamnetin-3-O-glucoside or by adding a hydroxyl group to the B ring of astragalin, was evaluated for neurite outgrowth-promoting activity and was compared with the activities of isorhamnetin-3-O-glucoside and astragalin. The activities of isorhamnetin, kaempferol, and quercetin, aglycones corresponding to isorhamnetin-3-O-glucoside, astragalin, and isoquercitrin, respectively, were also evaluated. Isorhamnetin-3-O-glucoside and astragalin showed much stronger neurite outgrowth-promoting activities than the activities of the other tested flavonoids. They exhibited relatively weak anti-oxidant activities and moderate AChE inhibitory activities compared to the activities of the other tested flavonoids. Isorhamnetin-3-O-glucoside and astragalin promoted morphological neurite outgrowth and the expression of neurofilaments induced by NGF in PC12 cells. Isorhamnetin-3-O-glucoside and astragalin might be candidate compounds as neural differentiation agents in peripheral nerves and functional food ingredients preventing cognitive decline.
|
掲載誌名 |
Molecules
|
ISSN | 14203049
|
出版者 | MDPI
|
巻 | 27
|
号 | 22
|
開始ページ | 7670
|
発行日 | 2022-11-08
|
権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
|
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
出版社版
|
部局 |
生物資源系
|