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ID 118068
著者
Koga, Takeru Tokushima University
Ito, Hideyuki Okayama Prefectural University
Iwaoka, Yuji Okayama Prefectural University
Noshita, Toshiro Prefectural University of Hiroshima|Gifu University of Medical Science
田井, 章博 Prefectural University of Hiroshima|Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Paeonia lactiflora
PC12 cells
NGF
isorhamnetin-3-O-glucoside
astragalin
neurite outgrowth-promoting activity
資料タイプ
学術雑誌論文
抄録
Isorhamnetin-3-O-glucoside and astragalin, flavonol glucosides, were isolated from the petals of Paeonia lactiflora as neurite outgrowth-promoting compounds. Isoquercitrin, formed by demethylating the B ring of isorhamnetin-3-O-glucoside or by adding a hydroxyl group to the B ring of astragalin, was evaluated for neurite outgrowth-promoting activity and was compared with the activities of isorhamnetin-3-O-glucoside and astragalin. The activities of isorhamnetin, kaempferol, and quercetin, aglycones corresponding to isorhamnetin-3-O-glucoside, astragalin, and isoquercitrin, respectively, were also evaluated. Isorhamnetin-3-O-glucoside and astragalin showed much stronger neurite outgrowth-promoting activities than the activities of the other tested flavonoids. They exhibited relatively weak anti-oxidant activities and moderate AChE inhibitory activities compared to the activities of the other tested flavonoids. Isorhamnetin-3-O-glucoside and astragalin promoted morphological neurite outgrowth and the expression of neurofilaments induced by NGF in PC12 cells. Isorhamnetin-3-O-glucoside and astragalin might be candidate compounds as neural differentiation agents in peripheral nerves and functional food ingredients preventing cognitive decline.
掲載誌名
Molecules
ISSN
14203049
出版者
MDPI
27
22
開始ページ
7670
発行日
2022-11-08
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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言語
eng
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部局
生物資源系