ID | 118623 |
Author |
Okano, Yoshio
National Hospital Organization Kochi Hospital
Kunishige, Michihiro
National Hospital Organization Kochi Hospital
Kondo, Yoshihiro
National Hospital Organization Kochi Hospital
Kadota, Naoki
National Hospital Organization Kochi Hospital
Morishita, Atsushi
National Hospital Organization Kochi Hospital
Naruse, Keishi
National Hospital Organization Kochi Hospital
Machida, Hisanori
National Hospital Organization Kochi Hospital
Hatakeyama, Nobuo
National Hospital Organization Kochi Hospital
Hino, Hiroyuki
National Hospital Organization Kochi Hospital
Shinohara, Tsutomu
Tokushima University
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Takeuchi, Eiji
National Hospital Organization Kochi Hospital
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Keywords | advanced squamous cell carcinoma of the lung
immune checkpoint inhibitor
induction immunochemotherapy
pathological complete response
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Content Type |
Journal Article
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Description | Immune checkpoint inhibitors (ICIs) have caused a paradigm shift in the treatment of lung cancer. Here, we encountered a case of inoperable locally advanced squamous cell carcinoma of the lung that became operable with pembrolizumab-based immunochemotherapy and achieved a pathological complete response. An 82-year-old man suspected of having lung cancer was referred to our hospital. The patient was clinically diagnosed with left upper lobe squamous cell carcinoma cT2aN3M0 c-stage IIIC. Immunostaining revealed the expression of programmed death-ligand 1 in 60% of tumor cells. The cancer cells disappeared after two cycles of chemotherapy with carboplatin and nanoparticle albumin-bound paclitaxel plus pembrolizumab. As the abnormal accumulation of 18F-fluorodeoxyglucose (FDG) on FDG-positron emission tomography/computed tomography before chemotherapy almost disappeared after pembrolizumab-based immunochemotherapy, left upper lobectomy and lymph node dissection were performed. No cancer cells were pathologically detected from the resected tissue. Therefore, ICIs combined with chemotherapy may enable inoperable advanced lung cancer patients to undergo surgery and achieve a complete response.
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Journal Title |
Thoracic Cancer
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ISSN | 17597714
17597706
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Publisher | China Lung Oncology Group|John Wiley & Sons Australia
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Volume | 13
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Issue | 3
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Start Page | 510
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End Page | 513
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Published Date | 2021-12-20
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Rights | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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language |
eng
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departments |
Medical Sciences
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