直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 118623
著者
Okano, Yoshio National Hospital Organization Kochi Hospital
國重, 道大 National Hospital Organization Kochi Hospital
Kondo, Yoshihiro National Hospital Organization Kochi Hospital
Kadota, Naoki National Hospital Organization Kochi Hospital
森下, 敦司 National Hospital Organization Kochi Hospital
Naruse, Keishi National Hospital Organization Kochi Hospital
Machida, Hisanori National Hospital Organization Kochi Hospital
Hatakeyama, Nobuo National Hospital Organization Kochi Hospital
Hino, Hiroyuki National Hospital Organization Kochi Hospital
先山, 正二 National Hospital Organization Kochi Hospital KAKEN研究者をさがす
Takeuchi, Eiji National Hospital Organization Kochi Hospital
キーワード
advanced squamous cell carcinoma of the lung
immune checkpoint inhibitor
induction immunochemotherapy
pathological complete response
資料タイプ
学術雑誌論文
抄録
Immune checkpoint inhibitors (ICIs) have caused a paradigm shift in the treatment of lung cancer. Here, we encountered a case of inoperable locally advanced squamous cell carcinoma of the lung that became operable with pembrolizumab-based immunochemotherapy and achieved a pathological complete response. An 82-year-old man suspected of having lung cancer was referred to our hospital. The patient was clinically diagnosed with left upper lobe squamous cell carcinoma cT2aN3M0 c-stage IIIC. Immunostaining revealed the expression of programmed death-ligand 1 in 60% of tumor cells. The cancer cells disappeared after two cycles of chemotherapy with carboplatin and nanoparticle albumin-bound paclitaxel plus pembrolizumab. As the abnormal accumulation of 18F-fluorodeoxyglucose (FDG) on FDG-positron emission tomography/computed tomography before chemotherapy almost disappeared after pembrolizumab-based immunochemotherapy, left upper lobectomy and lymph node dissection were performed. No cancer cells were pathologically detected from the resected tissue. Therefore, ICIs combined with chemotherapy may enable inoperable advanced lung cancer patients to undergo surgery and achieve a complete response.
掲載誌名
Thoracic Cancer
ISSN
17597714
17597706
出版者
China Lung Oncology Group|John Wiley & Sons Australia
13
3
開始ページ
510
終了ページ
513
発行日
2021-12-20
権利情報
This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系