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ID 109717
Title Alternative
早産児では尿中アンジオテンシノーゲンの排泄量が増加している
Urinary angiotensinogen during renal development in neonates
Author
Suzue, Masashi The University of Tokushima
Saijo, Takahiko The University of Tokushima
Keywords
Renin–angiotensin system
Neonates
Renal development
Gestational age
Preterm
Content Type
Thesis or Dissertation
Description
Background
All components of the renin-angiotensin system (RAS) are abundantly synthesized in the developing kidney, suggesting that the RAS plays an important role in renal development. To examine this system in human neonates, we measured urinary angiotensinogen levels in preterm and full-term neonates, and examined the relationship between urinary angiotensinogen levels and gestational age.
Methods
Urine and plasma samples were collected from 20 preterm and 18 full-term neonates at birth. Angiotensinogen levels were measured using enzyme-linked immunosorbent assay.
Results
Plasma angiotensinogen concentrations were not increased in preterm neonates compared to that in full-term neonates (P = 0.7288). However, the urinary angiotensinogen-to-creatinine ratio was significantly higher in preterm neonates compared to that in full-term neonates (P = 0.0011). Importantly, the urinary angiotensinogen-to-creatinine ratio dropped significantly with increasing gestational age (P = 0.0010), whereas the plasma angiotensinogen concentration was not correlated with gestational age (P = 0.7814).
Conclusions
These results suggest that urinary angiotensinogen levels may indicate the involvement of intrarenal RAS activation in prenatal renal development.
Journal Title
Clinical and Experimental Nephrology
ISSN
13421751
14377799
NCID
AA11619535
AA11126935
Publisher
Japanese Society of Nephrology|Springer nature
Volume
19
Issue
2
Start Page
293
End Page
297
Published Date
2014-05-03
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606211001.pdf
論文本文 : LID201703211001.pdf
本論文は, 著者Masashi Suzueの学位論文として提出され, 学位審査・授与の対象となっている。
The final publication is available at Springer via https://doi.org/10.1007/s10157-014-0977-y
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2901号
Diploma Number
甲医第1275号
Granted Date
2016-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences