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ID 109717
タイトル別表記
早産児では尿中アンジオテンシノーゲンの排泄量が増加している
Urinary angiotensinogen during renal development in neonates
著者
鈴江, 真史 徳島大学大学院医科学教育部(医学専攻)
Saijo, Takahiko The University of Tokushima
キーワード
Renin–angiotensin system
Neonates
Renal development
Gestational age
Preterm
資料タイプ
学位論文
抄録
Background
All components of the renin-angiotensin system (RAS) are abundantly synthesized in the developing kidney, suggesting that the RAS plays an important role in renal development. To examine this system in human neonates, we measured urinary angiotensinogen levels in preterm and full-term neonates, and examined the relationship between urinary angiotensinogen levels and gestational age.
Methods
Urine and plasma samples were collected from 20 preterm and 18 full-term neonates at birth. Angiotensinogen levels were measured using enzyme-linked immunosorbent assay.
Results
Plasma angiotensinogen concentrations were not increased in preterm neonates compared to that in full-term neonates (P = 0.7288). However, the urinary angiotensinogen-to-creatinine ratio was significantly higher in preterm neonates compared to that in full-term neonates (P = 0.0011). Importantly, the urinary angiotensinogen-to-creatinine ratio dropped significantly with increasing gestational age (P = 0.0010), whereas the plasma angiotensinogen concentration was not correlated with gestational age (P = 0.7814).
Conclusions
These results suggest that urinary angiotensinogen levels may indicate the involvement of intrarenal RAS activation in prenatal renal development.
掲載誌名
Clinical and Experimental Nephrology
ISSN
13421751
14377799
cat書誌ID
AA11619535
AA11126935
出版者
Japanese Society of Nephrology|Springer nature
19
2
開始ページ
293
終了ページ
297
発行日
2014-05-03
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201606211001.pdf
論文本文 : LID201703211001.pdf
本論文は, 著者Masashi Suzueの学位論文として提出され, 学位審査・授与の対象となっている。
The final publication is available at Springer via https://doi.org/10.1007/s10157-014-0977-y
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2901号
学位記番号
甲医第1275号
学位授与年月日
2016-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系