ID 110155
Author
Session, Adam M
Uno, Yoshinobu
Kwon, Taejoon
Chapman, Jarrod A.
Toyoda, Atsushi
Takahashi, Shuji
Fukui, Akimasa
Hikosaka, Akira
Suzuki, Atsushi
Kondo, Mariko
Heeringen, Simon J. van
Quigley, Ian
Heinz, Sven
Ogino, Hajime
Ochi, Haruki
Hellsten, Uffe
Lyons, Jessica B.
Simakov, Oleg
Putnam, Nicholas
Stites, Jonathan
Kuroki, Yoko
Tanaka, Toshiaki
Michiue, Tatsuo
Watanabe, Minoru Institute of Institution of Liberal Arts and Fundamental Education, Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Bogdanovic, Ozren
Lister, Ryan
Georgiou, Georgios
Paranjpe, Sarita S.
Kruijsbergen, Ila van
Shu, Shengquiang
Carlson, Joseph
Kinoshita, Tsutomu
Ohta, Yuko
Mawaribuchi, Shuuji
Jenkins, Jerry
Grimwood, Jane
Schmutz, Jeremy
Mitros, Therese
Mozaffari, Sahar V.
Suzuki, Yutaka
Haramoto, Yoshikazu
Yamamoto, Takamasa S.
Takagi, Chiyo
Heald, Rebecca
Miller, Kelly
Haudenschild, Christian
Kitzman, Jacob
Nakayama, Takuya
Izutsu, Yumi
Robert, Jacques
Fortriede, Joshua
Burns, Kevin
Lotay, Vaneet
Karimi, Kamran
Yasuoka, Yuuri
Dichmann, Darwin S.
Flajnik, Martin F.
Houston, Douglas W.
Shendure, Jay
DuPasquier, Louis
Vize, Peter D.
Zorn, Aaron M.
Ito, Michihiko
Marcotte, Edward M.
Wallingford, John B.
Ito, Yuzuru
Asashima, Makoto
Ueno, Naoto
Matsuda, Yoichi
Veenstra, Gert Jan C.
Fujiyama, Asao
Harland, Richard M.
Taira, Masanori
Rokhsar, Daniel S.
Content Type
Journal Article
Description
To explore the origins and consequences of tetraploidy in the African clawed frog, we sequenced the Xenopus laevis genome and compared it to the related diploid X. tropicalis genome. We characterize the allotetraploid origin of X. laevis by partitioning its genome into two homoeologous subgenomes, marked by distinct families of ‘fossil’ transposable elements. On the basis of the activity of these elements and the age of hundreds of unitary pseudogenes, we estimate that the two diploid progenitor species diverged around 34 million years ago (Ma) and combined to form an allotetraploid around 17–18 Ma. More than 56% of all genes were retained in two homoeologous copies. Protein function, gene expression, and the amount of conserved flanking sequence all correlate with retention rates. The subgenomes have evolved asymmetrically, with one chromosome set more often preserving the ancestral state and the other experiencing more gene loss, deletion, rearrangement, and reduced gene expression.
Journal Title
Nature
ISSN
00280836
14764687
NCID
AA11726193
Volume
538
Start Page
336
End Page
343
Sort Key
336
Published Date
2016-10-20
Remark
Copyright © 2016 This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Liberal Arts and Sciences