ID 111464
Title Alternative
ELDERLY PATIENT WITH ACROMEGALY
Author
Wada, Michiko The University of Tokushima
Azuma, Hiroyuki The University of Tokushima
Bando, Hiroshi The University of Tokushima KAKEN Search Researchers
Shintani, Yasumi The University of Tokushima
Saito, Shiro The University of Tokushima
Tamaki, Masaharu Tamaki Hospital
Arii, Hiroko The University of Tokushima
Keywords
Acromegaly
Advanced age
Octreotide
Content Type
Journal Article
Description
We encountered a 91-year-old patient with acromegalic features. The serum levels of growth hormone (GH) and insulin-like growth factor-I (IGF-I) were increased to 23.3ng/ml and to 268ng/ml, respectively. Both thyrotropin-releasing hormone and luteinizing hormone-releasing hormone tests demonstrated a 2-3 fold increase in the serum GH level. Magnetic resonance imaging disclosed a pituitary mass in the enlarged sella. The patient was diagnosed as having acromegaly due to overproduction of GH from a pituitary tumor. She manifested cardiac hypertrophy with severe aortic stenosis and mild hypertension, but without diabetes mellitus. After the administration of octreotide subcutaneously at a dose of 25 to 50μg daily for 20 days, the serum GH level increased transiently but decreased rapidly to approximately half the initial level, and suppression of the GH level persisted thereafter for over 2.5 months. This patient seems to be the oldest patient with acromegaly among those reported in Japan.
Journal Title
Endocrine Journal
ISSN
13484540
09188959
NCID
AA10901436
Publisher
The Japan Endocrine Society
Volume
43
Issue
6
Start Page
715
End Page
718
Published Date
1996
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences