ID 111464
タイトル別表記
ELDERLY PATIENT WITH ACROMEGALY
著者
Wada, Michiko The University of Tokushima
東, 博之 The University of Tokushima
板東, 浩 The University of Tokushima KAKEN研究者をさがす
Shintani, Yasumi The University of Tokushima
Saito, Shiro The University of Tokushima
Tamaki, Masaharu Tamaki Hospital
Arii, Hiroko The University of Tokushima
キーワード
Acromegaly
Advanced age
Octreotide
資料タイプ
学術雑誌論文
抄録
We encountered a 91-year-old patient with acromegalic features. The serum levels of growth hormone (GH) and insulin-like growth factor-I (IGF-I) were increased to 23.3ng/ml and to 268ng/ml, respectively. Both thyrotropin-releasing hormone and luteinizing hormone-releasing hormone tests demonstrated a 2-3 fold increase in the serum GH level. Magnetic resonance imaging disclosed a pituitary mass in the enlarged sella. The patient was diagnosed as having acromegaly due to overproduction of GH from a pituitary tumor. She manifested cardiac hypertrophy with severe aortic stenosis and mild hypertension, but without diabetes mellitus. After the administration of octreotide subcutaneously at a dose of 25 to 50μg daily for 20 days, the serum GH level increased transiently but decreased rapidly to approximately half the initial level, and suppression of the GH level persisted thereafter for over 2.5 months. This patient seems to be the oldest patient with acromegaly among those reported in Japan.
掲載誌名
Endocrine Journal
ISSN
13484540
09188959
cat書誌ID
AA10901436
出版者
The Japan Endocrine Society
43
6
開始ページ
715
終了ページ
718
発行日
1996
EDB ID
146078
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系