ID 111570
Title Alternative
Pathological Examinations and Cancer Drugs
Author
Yamashita, Michiko Tokushima Red Cross Hospital
Keywords
cancer
pathology
formalin-fixed paraffin embedded block
FFPE
molecular targeted drugs
Content Type
Journal Article
Description
The aging rate of the Tokushima prefecture is reaching globally top levels, while its cancer morbidity rate also rises. Malignant tumors can develop from almost any site in the body. Each tumor has unique, individual growth speeds. In pathological examination, a histological name is determined as ditailedly as possible to clarify the growth pattern and the treatment strategy of the tumor. Malignant tumors can be lethal, but according to one study they hardly require prolonged nursing care.
Histological diagnosis requires the following procedures : tumor identification, surgical dissection, fixing, dehydration, paraffin embedding, thin sectioning, staining, sealing, labeling and microscopic observation. Formalin-fixed paraffin embedded blocks, which help in the indication of molecular targeted drugs are generated through these processes. Since many targeted therapies block the EGFR-RAS-MAPK pathway, it is potentially one of the main mechanisms of cancer growth.
Our most urgent needs include appropriate explanations about variety and “draggability” of the cancers and cultivating patients’ “will to live.” To maintain the dignity of cancer patients, we must assemble a fully developed cancer team that includes active pathologists in each local community.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
74
Issue
1-2
Start Page
7
End Page
12
Sort Key
7
Published Date
2018-04-25
FullText File
language
jpn
TextVersion
Publisher