Pathological Examinations and Cancer Drugs
Yamashita, Michiko Tokushima Red Cross Hospital
formalin-fixed paraffin embedded block
molecular targeted drugs
The aging rate of the Tokushima prefecture is reaching globally top levels, while its cancer morbidity rate also rises. Malignant tumors can develop from almost any site in the body. Each tumor has unique, individual growth speeds. In pathological examination, a histological name is determined as ditailedly as possible to clarify the growth pattern and the treatment strategy of the tumor. Malignant tumors can be lethal, but according to one study they hardly require prolonged nursing care.
Histological diagnosis requires the following procedures : tumor identification, surgical dissection, fixing, dehydration, paraffin embedding, thin sectioning, staining, sealing, labeling and microscopic observation. Formalin-fixed paraffin embedded blocks, which help in the indication of molecular targeted drugs are generated through these processes. Since many targeted therapies block the EGFR-RAS-MAPK pathway, it is potentially one of the main mechanisms of cancer growth.
Our most urgent needs include appropriate explanations about variety and “draggability” of the cancers and cultivating patients’ “will to live.” To maintain the dignity of cancer patients, we must assemble a fully developed cancer team that includes active pathologists in each local community.
Shikoku Acta Medica
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