ID 111908
Author
Yamamoto, Jun The University of Tokushima
Maeda, Nami The University of Tokushima
Komiya, Chiaki The University of Tokushima
Tanaka, Tomohiro Tokyo Medical and Dental University
Denda, Masaya The University of Tokushima
Ebisuno, Koji The University of Tokushima
Nomura, Wataru Tokyo Medical and Dental University
Tamamura, Hirokazu Tokyo Medical and Dental University
Keywords
Cleavable linker
Fluoride-responsive
Traceable linker
Stimulus-responsive amino acid
Content Type
Journal Article
Description
A fluoride-responsive (FR) amino acid that induces amide bond cleavage upon the addition of a fluoride was developed, and it was applied to a FR traceable linker. By the use of an alkyne-containing peptide as a model of an alkynylatd target protein of a bioactive compound, introduction of the FR traceable linker onto the peptide was achieved. Subsequent fluoride induced cleavage of the linker followed by labeling of the released peptide derivative was also conducted to examine the potential applicability of the FR traceable linker to the enrichment and labeling of alkynylated target molecules.
Journal Title
Tetrahedron
ISSN
00404020
NCID
AA00861787
AA11539786
Publisher
Elsevier Ltd.
Volume
70
Issue
34
Start Page
5122
End Page
5127
Published Date
2014-06-06
Rights
© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences