ID 111908
著者
Yamamoto, Jun The University of Tokushima
Maeda, Nami The University of Tokushima
Komiya, Chiaki The University of Tokushima
Tanaka, Tomohiro Tokyo Medical and Dental University
Denda, Masaya The University of Tokushima
Ebisuno, Koji The University of Tokushima
Nomura, Wataru Tokyo Medical and Dental University
Tamamura, Hirokazu Tokyo Medical and Dental University
キーワード
Cleavable linker
Fluoride-responsive
Traceable linker
Stimulus-responsive amino acid
資料タイプ
学術雑誌論文
抄録
A fluoride-responsive (FR) amino acid that induces amide bond cleavage upon the addition of a fluoride was developed, and it was applied to a FR traceable linker. By the use of an alkyne-containing peptide as a model of an alkynylatd target protein of a bioactive compound, introduction of the FR traceable linker onto the peptide was achieved. Subsequent fluoride induced cleavage of the linker followed by labeling of the released peptide derivative was also conducted to examine the potential applicability of the FR traceable linker to the enrichment and labeling of alkynylated target molecules.
掲載誌名
Tetrahedron
ISSN
00404020
cat書誌ID
AA00861787
AA11539786
出版者
Elsevier Ltd.
70
34
開始ページ
5122
終了ページ
5127
発行日
2014-06-06
権利情報
© 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
278985
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系