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ID 111913
Author
Shigenaga, Akira The University of Tokushima KAKEN Search Researchers
Ogura, Keiji The University of Tokushima
Hirakawa, Hiroko The University of Tokushima
Yamamoto, Jun The University of Tokushima
Ebisuno, Koji The University of Tokushima
Miyamoto, Licht The University of Tokushima KAKEN Search Researchers
Keywords
hypoxia-responsive
peptide bond cleavage
reduction-responsive
stimulus-responsive
trimethyl lock
Content Type
Journal Article
Description
Utilization of a hypoxia-responsive amino acid is indispensable in the preparation of hypoxic tumor-specific peptidyl prodrugs. Bioreduction of a nitro group is among the most attractive triggering reactions in the hypoxia-responsive prodrugs. In this paper, design and synthesis of a reduction-responsive amino acid that induces peptide bond cleavage after reduction of the nitro group are described. Application to hypoxia-responsive peptide bond cleavage system is also reported.
Journal Title
ChemBioChem
ISSN
14397633
NCID
AA11617132
Publisher
WILEY‐VCH Verlag GmbH & Co. KGaA
Volume
13
Issue
7
Start Page
968
End Page
971
Published Date
2012-04-13
Remark
This is the peer reviewed version of the following article: Shigenaga, A. , Ogura, K. , Hirakawa, H. , Yamamoto, J. , Ebisuno, K. , Miyamoto, L. , Ishizawa, K. , Tsuchiya, K. and Otaka, A. (2012), Development of a Reduction‐Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells. ChemBioChem, 13: 968-971. doi:10.1002/cbic.201200141, which has been published in final form at https://doi.org/10.1002/cbic.201200141. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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DOI (Published Version)
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language
eng
TextVersion
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departments
Pharmaceutical Sciences
Medical Sciences