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ID 111913
著者
重永, 章 The University of Tokushima KAKEN研究者をさがす
Ogura, Keiji The University of Tokushima
Hirakawa, Hiroko The University of Tokushima
Yamamoto, Jun The University of Tokushima
Ebisuno, Koji The University of Tokushima
宮本, 理人 The University of Tokushima KAKEN研究者をさがす
キーワード
hypoxia-responsive
peptide bond cleavage
reduction-responsive
stimulus-responsive
trimethyl lock
資料タイプ
学術雑誌論文
抄録
Utilization of a hypoxia-responsive amino acid is indispensable in the preparation of hypoxic tumor-specific peptidyl prodrugs. Bioreduction of a nitro group is among the most attractive triggering reactions in the hypoxia-responsive prodrugs. In this paper, design and synthesis of a reduction-responsive amino acid that induces peptide bond cleavage after reduction of the nitro group are described. Application to hypoxia-responsive peptide bond cleavage system is also reported.
掲載誌名
ChemBioChem
ISSN
14397633
cat書誌ID
AA11617132
出版者
WILEY‐VCH Verlag GmbH & Co. KGaA
13
7
開始ページ
968
終了ページ
971
発行日
2012-04-13
備考
This is the peer reviewed version of the following article: Shigenaga, A. , Ogura, K. , Hirakawa, H. , Yamamoto, J. , Ebisuno, K. , Miyamoto, L. , Ishizawa, K. , Tsuchiya, K. and Otaka, A. (2012), Development of a Reduction‐Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells. ChemBioChem, 13: 968-971. doi:10.1002/cbic.201200141, which has been published in final form at https://doi.org/10.1002/cbic.201200141. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系
医学系