ID 111924
Author
Shimizu, Tatsuhiko Tokushima University
Miyajima, Rin Tokushima University
Sato, Kohei Tokushima University
Sakamoto, Ken Tokushima University
Naruse, Naoto Tokushima University
Kita, Miku Tokushima University
Keywords
C-Terminal peptide thioacids
N-Sulfanylethylanilide peptide
Hydrothiolysis
Phosphate buffer
Content Type
Journal Article
Description
A facile procedure has been developed for the synthesis of C-terminal peptide thioacids under mild conditions. A series of N-sulfanylethylanilide peptides prepared using Fmoc-based solid-phase peptide synthesis were successfully converted to the corresponding thioacids via a hydrothiolysis reaction in a phosphate buffer with only trace epimerization of the C-terminal amino acid.
Journal Title
Tetrahedron
ISSN
00404020
NCID
AA00861787
AA11539786
Publisher
Elsevier Ltd.
Volume
72
Issue
7
Start Page
992
End Page
998
Published Date
2015-12-29
Rights
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences