ID | 111924 |
Author |
Shimizu, Tatsuhiko
Tokushima University
Miyajima, Rin
Tokushima University
Sato, Kohei
Tokushima University
Sakamoto, Ken
Tokushima University
Naruse, Naoto
Tokushima University
Kita, Miku
Tokushima University
Otaka, Akira
Tokushima University
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Keywords | C-Terminal peptide thioacids
N-Sulfanylethylanilide peptide
Hydrothiolysis
Phosphate buffer
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Content Type |
Journal Article
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Description | A facile procedure has been developed for the synthesis of C-terminal peptide thioacids under mild conditions. A series of N-sulfanylethylanilide peptides prepared using Fmoc-based solid-phase peptide synthesis were successfully converted to the corresponding thioacids via a hydrothiolysis reaction in a phosphate buffer with only trace epimerization of the C-terminal amino acid.
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Journal Title |
Tetrahedron
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ISSN | 00404020
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NCID | AA00861787
AA11539786
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Publisher | Elsevier Ltd.
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Volume | 72
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Issue | 7
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Start Page | 992
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End Page | 998
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Published Date | 2015-12-29
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Rights | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Author
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departments |
Pharmaceutical Sciences
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