ID 111924
著者
Shimizu, Tatsuhiko Tokushima University
Miyajima, Rin Tokushima University
Sato, Kohei Tokushima University
Sakamoto, Ken Tokushima University
Naruse, Naoto Tokushima University
Kita, Miku Tokushima University
キーワード
C-Terminal peptide thioacids
N-Sulfanylethylanilide peptide
Hydrothiolysis
Phosphate buffer
資料タイプ
学術雑誌論文
抄録
A facile procedure has been developed for the synthesis of C-terminal peptide thioacids under mild conditions. A series of N-sulfanylethylanilide peptides prepared using Fmoc-based solid-phase peptide synthesis were successfully converted to the corresponding thioacids via a hydrothiolysis reaction in a phosphate buffer with only trace epimerization of the C-terminal amino acid.
掲載誌名
Tetrahedron
ISSN
00404020
cat書誌ID
AA00861787
AA11539786
出版者
Elsevier Ltd.
72
7
開始ページ
992
終了ページ
998
発行日
2015-12-29
権利情報
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
306185
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系