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ID 113447
Title Alternative
GH and GHRH responses to L-dopa in Cushing's disease
Author
Takahashi, Hideo The University of Tokushima
Bando, Hiroshi The University of Tokushima KAKEN Search Researchers
Zhang, Chenyu The University of Tokushima
Yamasaki, Ryuichi The University of Tokushima
Saito, Shiro The University of Tokushima
Content Type
Journal Article
Description
The function of the growth hormone-releasing hormone (GHRH)-growth hormone (GH) axis in Cushing's disease was studied by monitoring (a) the GH responses to GHRH loading and L-dopa loading, (b) the GHRH response to L-dopa loading, and (c) the daytime profiles of plasma GH concentration. GH release following GHRH and L-dopa was blunted in patients as compared to that in age-matched control subjects. However, GHRH release following L-dopa was similar in patients and controls. The plasma GH levels in four patients measured every 20 min by a highly sensitive immunoradiometric assay for GH showed pulsatile GH secretion at low levels during the observation period. These results indicate that GHRH release from the hypothalamus is preserved in patients with Cushing's disease, and support the hypothesis that glucocorticoid inhibits GH secretion by altering the hypothalamic somatostatin tone.
Journal Title
Acta Endocrinologica
ISSN
00015598
NCID
AA00507325
Volume
127
Issue
1
Start Page
13
End Page
17
Published Date
1992-07
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences