アクセス数 : ?
ダウンロード数 : ?
ID 113447
タイトル別表記
GH and GHRH responses to L-dopa in Cushing's disease
著者
Takahashi, Hideo The University of Tokushima
板東, 浩 The University of Tokushima KAKEN研究者をさがす
Zhang, Chenyu The University of Tokushima
Yamasaki, Ryuichi The University of Tokushima
Saito, Shiro The University of Tokushima
資料タイプ
学術雑誌論文
抄録
The function of the growth hormone-releasing hormone (GHRH)-growth hormone (GH) axis in Cushing's disease was studied by monitoring (a) the GH responses to GHRH loading and L-dopa loading, (b) the GHRH response to L-dopa loading, and (c) the daytime profiles of plasma GH concentration. GH release following GHRH and L-dopa was blunted in patients as compared to that in age-matched control subjects. However, GHRH release following L-dopa was similar in patients and controls. The plasma GH levels in four patients measured every 20 min by a highly sensitive immunoradiometric assay for GH showed pulsatile GH secretion at low levels during the observation period. These results indicate that GHRH release from the hypothalamus is preserved in patients with Cushing's disease, and support the hypothesis that glucocorticoid inhibits GH secretion by altering the hypothalamic somatostatin tone.
掲載誌名
Acta Endocrinologica
ISSN
00015598
cat書誌ID
AA00507325
127
1
開始ページ
13
終了ページ
17
発行日
1992-07
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系