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ID 115432
Author
Fujikawa, T Kanaiso Hospital
Kato, Y Kanaiso Hospital
Bando, Hiroshi Kanaiso Hospital|Tokushima University KAKEN Search Researchers
Kakutani, H Kanaiso Hospital
Kawata, T Kanaiso Hospital
Yamamoto, M Kanaiso Hospital
Wada, K Kanaiso Hospital
Ishikura, K Kanaiso Hospital
Shirai, Y Kanaiso Hospital
Narutaki, M Kanaiso Hospital
Matsuzaki, S Kanaiso Hospital
Waka, S Kanaiso Hospital
Keywords
Xultophy
Insulin Degludec/Liraglutide (IDegLira)
Type 2 Diabetes Mellitus
Hemodialysis
Content Type
Journal Article
Description
Background: Recent diabetic treatments include Insulin Degludec/ liraglutide (IDeg/Lira, Xultophy) in clinical practice. Authors have continued clinical research concerning diabetes, chronic renal failure, dialysis, and others.
Subjects and Methods: Ten patients with type 2 diabetes mellitus (T2DM) undergoing hemodialysis were investigated. They showed that ages 74.5 ± 5.9 years, M/F=6/4, BMI 21.1± 3.8kg/m2, hemodialysis duration 8.1 ± 5.7 years. At the beginning, fundamental data were Cre 8.2 ± 1.9 mg/dL, HbA1c 6.5 ± 0.8%. Xultophy was started on 5-12 doses and continued for 6 months with the same or 1-4 increased doses for better glycemic variability.
Results: Out of 10 subjects, the changes in HbA1c showed a decrease in 7, stable in 2, and an increase in 1. HbA1c value was 6.2 ± 0.8% in average at 6 months. There were no remarkable adverse effects by Xultophy for 6 months.
Discussion and Conclusion: Xultophy was started at 5-12 doses, which were remarkably lower doses than usual doses with satisfactory efficacy. One of the reasons may be from the characteristic of the patients, who were diabetic with undergoing hemodialysis. Another factor is possibly from liraglutide, which has hepatic clearance with potential vascular protective effects. These results are expected to become reference data for future research.
Journal Title
Diabetes Research : Open Access
Publisher
Asploro
Volume
2
Issue
3
Start Page
72
End Page
78
Published Date
2020-10-20
Rights
© 2020 Fujikawa T, Kato Y, Bando H, Kakutani H, Kawata T, Yamamoto M, Wada K, Ishikura K, Shirai Y, Narutaki M, Matsuzaki S, Waka S. This is an open-access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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language
eng
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departments
Medical Sciences