Hirakawa, Hiroko The University of Tokushima
Yamamoto, Jun The University of Tokushima
Ogura, Keiji The University of Tokushima
Denda, Masaya The University of Tokushima
Yamaguchi, Keiko The University of Tokushima
Itoh, Kohji The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Otaka, Akira The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Amide bond cleavage
Sphingolipids, recognized as membrane constructs and as key signaling molecules, have been studied to examine intracellular function. Some caged sphingolipids that release parent sphingolipids after exposure to UV-irradiation have been previously developed, but caged ceramide has yet to be reported. In this study, we report the design and synthesis of a caged ceramide. Photo-irradiation experiment clarified that the caged ceramide can be successfully converted to the parent ceramide by UV-irradiation. Introduction of an alkyne-handle moiety for further modification of the caged ceramide is also reported.
© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
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tet_67_22_3984.pdf 609 KB
tet_67_22_3984_si.pdf 4.94 MB