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Harada, Takeshi

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Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors
Author Harada, Takeshi/ Ozaki, Shuji/ Oda, Asuka/ Tsuji, Daisuke/ Ikegame, Akishige/ Iwasa, Masami/ Udaka, Kengo/ Fujii, Shiro/ Nakamura, Shingen/ Miki, Hirokazu/ Kagawa, Kumiko/ Kuroda, Yoshiaki/ Kawai, Shigeto/ Itoh, Kohji/ Yamada-Okabe, Hisafumi/ Matsumoto, Toshio/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title PLOS ONE
Volume 8
Issue 12
Published Date 2013-12-26
departments University Hospital Pharmaceutical Sciences Medical Sciences Institute of Advanced Medical Sciences
Class 1 HDAC and HDAC6 inhibition inversely regulates CD38 induction in myeloma cells via interferon‐α and ATRA
Author Bat‐Erdene, Ariunzaya/ Nakamura, Shingen/ Oda, Asuka/ Iwasa, Masami/ Teramachi, Jumpei/ Ashtar, Mohannad/ Harada, Takeshi/ Miki, Hirokazu/ Tenshin, Hirofumi/ Hiasa, Masahiro/ Fujii, Shiro/ Sogabe, Kimiko/ Oura, Masahiro/ Udaka, Kengo/ Kagawa, Kumiko/ Yoshida, Sumiko/ Aihara, Ken-ichi/ Kurahashi, Kiyoe/ Endo, Itsuro/ Abe, Masahiro/
Content Type Journal Article
Journal Title British Journal of Haematology
Volume 185
Issue 5
Published Date 2018-11-26
departments Medical Sciences Oral Sciences University Hospital
PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ
Author Iwasa, Masami/ Harada, Takeshi/ Oda, Asuka/ Bat-Erdene, Ariunzaya/ Teramachi, Jumpei/ Tenshin, Hirofumi/ Ashtar, Mohannad/ Oura, Masahiro/ Sogabe, Kimiko/ Udaka, Kengo/ Fujii, Shiro/ Nakamura, Shingen/ Miki, Hirokazu/ Kagawa, Kumiko/ Ozaki, Shuji/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title Oncotarget
Volume 10
Issue 20
Published Date 2019-03-08
departments University Hospital Oral Sciences Medical Sciences
TAK1 inhibition subverts the osteoclastogenic action of TRAIL while potentiating its antimyeloma effects
Author Tenshin, Hirofumi/ Teramachi, Jumpei/ Oda, Asuka/ Amachi, Ryota/ Hiasa, Masahiro/ Bat-Erdene, Ariunzaya/ Watanabe, Keiichiro/ Iwasa, Masami/ Harada, Takeshi/ Fujii, Shiroh/ Kagawa, Kumiko/ Sogabe, Kimiko/ Nakamura, Shingen/ Miki, Hirokazu/ Kurahashi, Kiyoe/ Yoshida, Sumiko/ Aihara, Kenichi/ Endo, Itsuro/ Tanaka, Eiji/ Matsumoto, Toshio/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title Blood Advances
Volume 1
Issue 24
Published Date 2017-10-26
departments Oral Sciences University Hospital Medical Sciences Institute of Advanced Medical Sciences
A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche : biologic and clinical applications
Author Jakubikova, Jana/ Cholujova, Danka/ Hideshima, Teru/ Gronesova, Paulina/ Soltysova, Andrea/ Harada, Takeshi/ Joo, Jungnam/ Kong, Sun-Young/ Szalat, Raphael E./ Richardson, Paul G./ Munshi, Nikhil C./ Dorfman, David M./ Anderson, Kenneth C./
Content Type Journal Article
Journal Title Oncotarget
Volume 7
Issue 47
Published Date 2016-10-13
departments University Hospital
Activating transcription factor 4, an ER stress mediator , is required for, but excessive ER stress suppresses osteoblastogenesis by bortezomib
Author Nakamura, Shingen/ Miki, Hirokazu/ Kido, Shinsuke/ Nakano, Ayako/ Hiasa, Masahiro/ Oda, Asuka/ Amou, Hiroe/ Watanabe, Keiichiro/ Harada, Takeshi/ Fujii, Shiro/ Takeuchi, Kyoko/ Kagawa, Kumiko/ Ozaki, Shuji/ Matsumoto, Toshio/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title International Journal of Hematology
Volume 98
Issue 1
Published Date 2013-05-25
departments Medical Sciences University Hospital Oral Sciences Institute of Advanced Medical Sciences
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation
Author Hanson, Derek James/ Nakamura, Shingen/ Amachi, Ryota/ Hiasa, Masahiro/ Oda, Asuka/ Tsuji, Daisuke/ Itoh, Kohji/ Harada, Takeshi/ Horikawa, Kazuki/ Teramachi, Jumpei/ Miki, Hirokazu/ Matsumoto, Toshio/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title Oncotarget
Volume 6
Issue 32
Published Date 2015-09-10
departments Medical Sciences Oral Sciences Pharmaceutical Sciences University Hospital Institute of Advanced Medical Sciences
Polyclonal Immunoglobulin Recovery after Autologous Stem Cell Transplantation Is an Independent Prognostic Factor for Survival Outcome in Patients with Multiple Myeloma
Author Ozaki, Shuji/ Harada, Takeshi/ Yagi, Hikaru/ Sekimoto, Etsuko/ Shibata, Hironobu/ Shigekiyo, Toshio/ Fujii, Shiro/ Nakamura, Shingen/ Miki, Hirokazu/ Kagawa, Kumiko/ Abe, Masahiro/
Content Type Journal Article
Journal Title Cancers
Volume 12
Issue 1
Published Date 2019-12-18
departments University Hospital Medical Sciences
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells
Author Asano, Jin/ Nakano, Ayako/ Oda, Asuka/ Amou, Hiroe/ Hiasa, Masahiro/ Takeuchi, Kyoko/ Miki, Hirokazu/ Nakamura, Shingen/ Harada, Takeshi/ Fujii, Shiro/ Kagawa, Kumiko/ Endo, Itsuro/ Yata, Kenichiro/ Sakai, Akira/ Ozaki, Shuji/ Matsumoto, Toshio/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title Leukemia
Volume 25
Issue 7
Published Date 2011-04-08
departments Oral Sciences University Hospital Medical Sciences Institute of Advanced Medical Sciences
Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling
Author Ho, Matthew/ Chen, Tianzeng/ Liu, Jiye/ Dowling, Paul/ Hideshima, Teru/ Zhang, Li/ Morelli, Eugenio/ Camci-Unal, Gulden/ Wu, Xinchen/ Tai, Yu-Tzu/ Wen, Kenneth/ Samur, Mehmet/ Schlossman, Robert L./ Mazitschek, Ralph/ Kavanagh, Emma L./ Lindsay, Sinéad/ Harada, Takeshi/ McCann, Amanda/ Anderson, Kenneth C./ O’Gorman, Peter/ Bianchi, Giada/
Content Type Journal Article
Journal Title Leukemia
Volume 34
Issue 1
Published Date 2019-05-29
departments University Hospital
The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis : Suppressive Effects of Febuxostat
Author Ashtar, Mohannad/ Tenshin, Hirofumi/ Teramachi, Jumpei/ Bat-Erdene, Ariunzaya/ Hiasa, Masahiro/ Oda, Asuka/ Tanimoto, Kotaro/ Shimizu, So/ Higa, Yoshiki/ Harada, Takeshi/ Oura, Masahiro/ Sogabe, Kimiko/ Nakamura, Shingen/ Fujii, Shiro/ Sumitani, Ryohei/ Miki, Hirokazu/ Udaka, Kengo/ Takahashi, Mamiko/ Kagawa, Kumiko/ Endo, Itsuro/ Tanaka, Eiji/ Matsumoto, Toshio/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title Cancers
Volume 12
Issue 4
Published Date 2020-04-09
departments Oral Sciences University Hospital Medical Sciences Institute of Advanced Medical Sciences
TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma
Author Teramachi, Jumpei/ Tenshin, Hirofumi/ Hiasa, Masahiro/ Oda, Asuka/ Bat-Erdene, Ariunzaya/ Harada, Takeshi/ Nakamura, Shingen/ Ashtar, Mohannad/ Shimizu, So/ Iwasa, Masami/ Sogabe, Kimiko/ Oura, Masahiro/ Fujii, Shiro/ Kagawa, Kumiko/ Miki, Hirokazu/ Endo, Itsuro/ Haneji, Tatsuji/ Matsumoto, Toshio/ Abe, Masahiro/
Content Type Journal Article
Journal Title Haematologica
Volume 106
Issue 5
Published Date 2020-04-09
departments Oral Sciences University Hospital Medical Sciences Institute of Advanced Medical Sciences
Pathogenesis and treatment of multiple myeloma bone disease
Author Hiasa, Masahiro/ Harada, Takeshi/ Tanaka, Eiji/ Abe, Masahiro/
Content Type Journal Article
Journal Title Japanese Dental Science Review
Volume 57
Published Date 2021-09-23
departments Oral Sciences University Hospital Medical Sciences
TGF-β-activated kinase-1 inhibitor LL-Z1640-2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF-α and RANKL expression
Author Tenshin, Hirofumi/ Teramachi, Jumpei/ Ashtar, Mohannad/ Hiasa, Masahiro/ Inoue, Yusuke/ Oda, Asuka/ Tanimoto, Kotaro/ Shimizu, So/ Higa, Yoshiki/ Harada, Takeshi/ Oura, Masahiro/ Sogabe, Kimiko/ Hara, Tomoyo/ Sumitani, Ryohei/ Maruhashi, Tomoko/ Sebe, Mayu/ Tsutsumi, Rie/ Sakaue, Hiroshi/ Endo, Itsuro/ Matsumoto, Toshio/ Tanaka, Eiji/ Abe, Masahiro/
Content Type Journal Article
Journal Title Clinical & Translational Immunology
Volume 11
Issue 1
Published Date 2022-01-19
departments Oral Sciences University Hospital Medical Sciences Institute of Advanced Medical Sciences
Mechanical unloading aggravates bone destruction and tumor expansion in myeloma
Author Tanimoto, Kotaro/ Hiasa, Masahiro/ Tenshin, Hirofumi/ Teramachi, Jumpei/ Oda, Asuka/ Harada, Takeshi/ Higa, Yoshiki/ Sogabe, Kimiko/ Oura, Masahiro/ Sumitani, Ryohei/ Hara, Tomoyo/ Endo, Itsuro/ Matsumoto, Toshio/ Tanaka, Eiji/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title Haematologica
Volume 107
Issue 3
Published Date 2021-11-18
departments Oral Sciences University Hospital Medical Sciences Institute of Advanced Medical Sciences
Myeloma–Bone Interaction : A Vicious Cycle via TAK1–PIM2 Signaling
Author Harada, Takeshi/ Hiasa, Masahiro/ Teramachi, Jumpei/ Abe, Masahiro/
Content Type Journal Article
Journal Title Cancers
Volume 13
Issue 17
Published Date 2021-09-03
departments University Hospital Oral Sciences Medical Sciences
Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative
Author Nakayama, Atsushi/ Nakamura, Tenta/ Ara, Tabassum/ Fukuta, Tatsuya/ Karanjit, Sangita/ Harada, Takeshi/ Oda, Asuka/ Sato, Hideo/ Abe, Masahiro/ Kogure, Kentaro/ Namba, Kosuke/
Content Type Journal Article
Journal Title Tetrahedron Letters
Volume 74
Published Date 2021-05-10
departments Pharmaceutical Sciences University Hospital Medical Sciences
The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2
Author Higa, Yoshiki/ Hiasa, Masahiro/ Tenshin, Hirofumi/ Nakaue, Emiko/ Tanaka, Mariko/ Kim, Sooha/ Nakagawa, Motosumi/ Shimizu, So/ Tanimoto, Kotaro/ Teramachi, Jumpei/ Harada, Takeshi/ Oda, Asuka/ Oura, Masahiro/ Sogabe, Kimiko/ Hara, Tomoyo/ Sumitani, Ryohei/ Maruhashi, Tomoko/ Yamagami, Hiroki/ Endo, Itsuro/ Matsumoto, Toshio/ Tanaka, Eiji/ Abe, Masahiro/
Content Type Thesis or Dissertation
Journal Title Antioxidants
Volume 12
Issue 1
Published Date 2023-01-05
departments Oral Sciences University Hospital Medical Sciences Institute of Advanced Medical Sciences
リウマチ様関節炎に対する免疫抑制療法中に発症した成人T細胞性白血病/リンパ腫の1例
Author Yamaguchi, Sumiyo/ Nakamura, Shingen/ Sumida, Satoshi/ Maeda, Yusaku/ Oura, Masahiro/ Takahashi, Mamiko/ Iwasa, Masami/ Harada, Takeshi/ Fujii, Shiro/ Miki, Hirokazu/ Kagawa, Kumiko/ Kishi, Jun/ Abe, Masahiro/
Content Type Journal Article
Journal Title Shikoku Acta Medica
Volume 73
Issue 5-6
Published Date 2017-12-25
departments Medical Sciences University Hospital
臍帯血移植が奏効した治療抵抗性肝脾型T細胞リンパ腫の１例
Author Fujii, Shiro/ Oura, Masahiro/ Sogabe, Kimiko/ Takahashi, Mamiko/ Harada, Takeshi/ Nakamura, Shingen/ Kagawa, Kumiko/ Abe, Masahiro/ Inoue, Yusuke/ Ikegame, Akishige/ Miki, Hirokazu/
Content Type Journal Article
Journal Title Shikoku Acta Medica
Volume 75
Issue 5-6
Published Date 2019-12-25
departments University Hospital Medical Sciences
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