| ID | 116924 |
| Author |
Miki, K
Hayashi Hospital
Bando, Hiroshi
Hayashi Hospital|Tokushima University|Japan Low Carbohydrate Diet Promotion Association
KAKEN Search Researchers
Hayashi, K
Hayashi Hospital
Dohi, A
Japan Low Carbohydrate Diet Promotion Association
Kamoto, A
Hayashi Hospital
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| Keywords | Glucagon-like peptide 1 receptor agonists (GLP-1 RAs)
Oral semaglutide (Rybelsus)
Sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC)
Fasting time period
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| Content Type |
Journal Article
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| Description | Recent pharmacological topic for diabetes includes clinical application of Glucagon-like peptide 1 receptor agonists (GLP-1 RAs). Among them, oral semaglutide (Rybelsus) has been developed as the first oral form of GLP-1RA by useful application of sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). Semaglutide concentration in the blood was compared when fasting time period after Rybelsus administration would be 15, 30, 60 and 120 minutes. As a result, the concentration ratio after 4 hours was 1.00, 1.67, 2.60 and 3.06, respectively. Authors have experienced a diabetic case of remarkable efficacy as HbA1c -1.4% and weight -5kg, who kept 3-4 hours fasting after Rybelsus intake.
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| Journal Title |
SunText Review of Medical & Clinical Research
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| ISSN | 27664813
|
| Publisher | SunText Reviews
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| Volume | 3
|
| Issue | 1
|
| Start Page | 150
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| Published Date | 2022-04-04
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| Rights | This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Medical Sciences
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