| ID | 111907 |
| Author |
Hirakawa, Hiroko
The University of Tokushima
Yamamoto, Jun
The University of Tokushima
Ogura, Keiji
The University of Tokushima
Denda, Masaya
The University of Tokushima
Yamaguchi, Keiko
The University of Tokushima
Itoh, Kohji
The University of Tokushima
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Otaka, Akira
The University of Tokushima
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|
| Keywords | Amide bond cleavage
Caged compound
Ceramide
Sphingolipid
UV-responsive
|
| Content Type |
Journal Article
|
| Description | Sphingolipids, recognized as membrane constructs and as key signaling molecules, have been studied to examine intracellular function. Some caged sphingolipids that release parent sphingolipids after exposure to UV-irradiation have been previously developed, but caged ceramide has yet to be reported. In this study, we report the design and synthesis of a caged ceramide. Photo-irradiation experiment clarified that the caged ceramide can be successfully converted to the parent ceramide by UV-irradiation. Introduction of an alkyne-handle moiety for further modification of the caged ceramide is also reported.
|
| Journal Title |
Tetrahedron
|
| ISSN | 00404020
|
| NCID | AA00861787
AA11539786
|
| Publisher | Elsevier Ltd.
|
| Volume | 67
|
| Issue | 22
|
| Start Page | 3984
|
| End Page | 3990
|
| Published Date | 2011-04-20
|
| Rights | © 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Author
|
| departments |
Pharmaceutical Sciences
|
