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Shigenaga, Akira

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Residue-selective C−H sulfenylation enabled by acid-activated S-acetamidomethyl cysteine sulfoxide with application to one-pot stapling and lipidation sequence
Author Ohkawachi, Kento/ Anzaki, Kaito/ Kobayashi, Daishiro/ Kyan, Ryuji/ Yasuda, Takuma/ Denda, Masaya/ Harada, Norio/ Shigenaga, Akira/ Inagaki, Nobuya/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 29
Issue 26
Published Date 2023-03-15
departments Pharmaceutical Sciences
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
Author Miyake, Masato/ Sobajima, Mitsuaki/ Kurahashi, Kiyoe/ Shigenaga, Akira/ Denda, Masaya/ Otaka, Akira/ Saio, Tomohide/ Sakane, Naoki/ Kosako, Hidetaka/ Oyadomari, Seiichi/
Content Type Journal Article
Journal Title Cell Chemical Biology
Volume 29
Issue 6
Published Date 2022-02-09
departments Institute of Advanced Medical Sciences University Hospital Pharmaceutical Sciences
Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation
Author Sato, Daiki/ Denda, Masaya/ Tsunematsu, Honoka/ Tanaka, Naonobu/ Konishi, Isamu/ Komiya, Chiaki/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 58
Issue 17
Published Date 2022-02-01
departments Pharmaceutical Sciences Bioscience and Bioindustry
Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety
Author Yamasaki, Misaki/ Seto, Yuika/ Ozono, Mizune/ Nakao, Michiyasu/ Shigenaga, Akira/ Otaka, Akira/ Sano, Shigeki/ Kogure, Kentaro/
Content Type Journal Article
Journal Title Biochemistry and Biophysics Reports
Volume 31
Published Date 2022-08-16
departments Pharmaceutical Sciences
Deprotection of S-Acetamidomethyl Cysteine with Copper (II) and 1,2-Aminothiols under Aerobic Conditions
Author Kobayashi, Daishiro/ Naruse, Naoto/ Denda, Masaya/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 18
Issue 42
Published Date 2020-08-20
departments Pharmaceutical Sciences
磁気浮上を利用した簡便な固相反応モニター法の開発
Author Shigenaga, Akira/ Otaka, Akira/
Content Type Others
Journal Title Chemical Biology
Volume 2
Issue 2
Published Date 2009-05-18
departments Pharmaceutical Sciences
Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis
Author Ohkawachi, Kento/ Kobayashi, Daishiro/ Morimoto, Kyohei/ Shigenaga, Akira/ Denda, Masaya/ Yamatsugu, Kenzo/ Kanai, Motomu/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 22
Issue 14
Published Date 2020-05-12
departments Pharmaceutical Sciences
Elucidation of inhibitor-binding pockets of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology
Author Kohiki, Taiki/ Kato, Yusuke/ Nishikawa, Yusuke/ Yorita, Kazuko/ Sagawa, Ikuko/ Denda, Masaya/ Inokuma, Tsubasa/ Shigenaga, Akira/ Fukui, Kiyoshi/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 15
Issue 25
Published Date 2017-05-05
departments Institute of Advanced Medical Sciences Technical Support Department Pharmaceutical Sciences
An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins
Author Morisaki, Takuya/ Denda, Masaya/ Yamamoto, Jun/ Tsuji, Daisuke/ Inokuma, Tsubasa/ Itoh, Kohji/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 52
Issue 42
Published Date 2016-04-26
departments Pharmaceutical Sciences
Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins
Author Yamamoto, Jun/ Denda, Masaya/ Maeda, Nami/ Kita, Miku/ Komiya, Chiaki/ Tanaka, Tomohiro/ Nomura, Wataru/ Tamamura, Hirokazu/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 12
Issue 23
Published Date 2014-04-17
departments Pharmaceutical Sciences
Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein
Author Ebisuno, Koji/ Denda, Masaya/ Ogura, Keiji/ Inokuma, Tsubasa/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Bioorganic & Medicinal Chemistry
Volume 22
Issue 11
Published Date 2014-04-13
departments Pharmaceutical Sciences
Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker
Author Yamamoto, Jun/ Maeda, Nami/ Komiya, Chiaki/ Tanaka, Tomohiro/ Denda, Masaya/ Ebisuno, Koji/ Nomura, Wataru/ Tamamura, Hirokazu/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Tetrahedron
Volume 70
Issue 34
Published Date 2014-06-06
departments Pharmaceutical Sciences
Labelling of Endogenous Target Protein via N–S Acyl Transfer-Mediated Activation of N-Sulfanylethylanilide
Author Denda, Masaya/ Morisaki, Takuya/ Kohiki, Taiki/ Yamamoto, Jun/ Sato, Kohei/ Sagawa, Ikuko/ Inokuma, Tsubasa/ Sato, Youichi/ Yamauchi, Aiko/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 14
Issue 26
Published Date 2016-05-31
departments Technical Support Department Pharmaceutical Sciences
Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System
Author Tsuda, Yusuke/ Shigenaga, Akira/ Tsuji, Kohei/ Denda, Masaya/ Sato, Kohei/ Kitakaze, Keisuke/ Nakamura, Takahiro/ Inokuma, Tsubasa/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemistryOpen
Volume 4
Issue 4
Published Date 2015-04-28
departments Pharmaceutical Sciences
Asymmetric Synthesis of α‐Amino Phosphonic Acids using Stable Imino Phosphonate as a Universal Precursor
Author Inokuma, Tsubasa/ Sakakibara, Takuya/ Someno, Takatoshi/ Masui, Kana/ Shigenaga, Akira/ Otaka, Akira/ Yamada, Ken-ichi/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 25
Issue 60
Published Date 2019-08-26
departments Pharmaceutical Sciences
CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity
Author Tanegashima, Kosuke/ Takahashi, Rena/ Nuriya, Hideko/ Iwase, Rina/ Naruse, Naoto/ Tsuji, Kohei/ Shigenaga, Akira/ Otaka, Akira/ Hara, Takahiko/
Content Type Journal Article
Journal Title EBioMedicine
Volume 24
Published Date 2017-09-14
departments Pharmaceutical Sciences
Development of Chemical Biology Tools Focusing on Peptide/Amide Bond Cleavage Reaction
Author Shigenaga, Akira/
Content Type Journal Article
Journal Title Chemical and Pharmaceutical Bulletin
Volume 67
Issue 11
Published Date 2019-11-01
departments Pharmaceutical Sciences
スクリプス研究所Janda研への留学経験を振り返る
Author Shigenaga, Akira/
Content Type Journal Article
Journal Title Journal of the Pharmaceutical Society of Japan
Volume 139
Issue 2
Published Date 2019-02-01
departments Pharmaceutical Sciences
Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence
Author Komiya, Chiaki/ Shigenaga, Akira/ Tsukimoto, Jun/ Ueda, Masahiro/ Morisaki, Takuya/ Inokuma, Tsubasa/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 55
Issue 49
Published Date 2019-05-23
departments Pharmaceutical Sciences
Light-induced propulsion of a giant liposome driven by peptide nanofibre growth
Author Inaba, Hiroshi/ Uemura, Akihito/ Morishita, Kazushi/ Kohiki, Taiki/ Shigenaga, Akira/ Otaka, Akira/ Matsuura, Kazunori/
Content Type Journal Article
Journal Title Scientific Reports
Volume 8
Published Date 2018-04-19
departments Pharmaceutical Sciences
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