Komiya, Chiaki Tokushima University
Aihara, Keisuke Tokushima University
Morishita, Ko Tokushima University
Ding, Hao Tokushima University
Inokuma, Tsubasa Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Otaka, Akira Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
A photo-responsive amide cleavage device was developed based on the asparagine imidation-mediated cleavage of peptide bonds during intein-mediated protein splicing. The chemical environment of the protein splicing process was mimicked by the incorporation of geminal dimethyl groups and a secondary amine unit in asparagine scaffold. Furthermore, the resulting photo-responsive device could induce the photo-triggered cleavage of an amide bond by the protection of the secondary amine unit with an o-nitrobenzyloxycarbonyl group.
The Journal of Organic Chemistry
This document is the Accepted Manuscript version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.joc.5b02399.
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joc_81_2_699.pdf 954 KB
joc_81_2_699_si.pdf 5.69 MB