ID | 111896 |
Author |
Komiya, Chiaki
Tokushima University
Aihara, Keisuke
Tokushima University
Morishita, Ko
Tokushima University
Ding, Hao
Tokushima University
Inokuma, Tsubasa
Tokushima University
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Otaka, Akira
Tokushima University
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Content Type |
Journal Article
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Description | A photo-responsive amide cleavage device was developed based on the asparagine imidation-mediated cleavage of peptide bonds during intein-mediated protein splicing. The chemical environment of the protein splicing process was mimicked by the incorporation of geminal dimethyl groups and a secondary amine unit in asparagine scaffold. Furthermore, the resulting photo-responsive device could induce the photo-triggered cleavage of an amide bond by the protection of the secondary amine unit with an o-nitrobenzyloxycarbonyl group.
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Journal Title |
The Journal of Organic Chemistry
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ISSN | 00223263
15206904
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NCID | AA00704100
AA12097242
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Publisher | ACS Publications
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Volume | 81
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Issue | 2
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Start Page | 699
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End Page | 707
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Published Date | 2015-12-08
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Rights | This document is the Accepted Manuscript version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.joc.5b02399.
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Author
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departments |
Pharmaceutical Sciences
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