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ダウンロード数 : ?
ID 111896
著者
Komiya, Chiaki Tokushima University
Aihara, Keisuke Tokushima University
Morishita, Ko Tokushima University
Ding, Hao Tokushima University
資料タイプ
学術雑誌論文
抄録
A photo-responsive amide cleavage device was developed based on the asparagine imidation-mediated cleavage of peptide bonds during intein-mediated protein splicing. The chemical environment of the protein splicing process was mimicked by the incorporation of geminal dimethyl groups and a secondary amine unit in asparagine scaffold. Furthermore, the resulting photo-responsive device could induce the photo-triggered cleavage of an amide bond by the protection of the secondary amine unit with an o-nitrobenzyloxycarbonyl group.
掲載誌名
The Journal of Organic Chemistry
ISSN
00223263
15206904
cat書誌ID
AA00704100
AA12097242
出版者
ACS Publications
81
2
開始ページ
699
終了ページ
707
発行日
2015-12-08
権利情報
This document is the Accepted Manuscript version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.joc.5b02399.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系