ID | 111896 |
著者 |
Komiya, Chiaki
Tokushima University
Aihara, Keisuke
Tokushima University
Morishita, Ko
Tokushima University
Ding, Hao
Tokushima University
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資料タイプ |
学術雑誌論文
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抄録 | A photo-responsive amide cleavage device was developed based on the asparagine imidation-mediated cleavage of peptide bonds during intein-mediated protein splicing. The chemical environment of the protein splicing process was mimicked by the incorporation of geminal dimethyl groups and a secondary amine unit in asparagine scaffold. Furthermore, the resulting photo-responsive device could induce the photo-triggered cleavage of an amide bond by the protection of the secondary amine unit with an o-nitrobenzyloxycarbonyl group.
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掲載誌名 |
The Journal of Organic Chemistry
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ISSN | 00223263
15206904
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cat書誌ID | AA00704100
AA12097242
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出版者 | ACS Publications
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巻 | 81
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号 | 2
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開始ページ | 699
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終了ページ | 707
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発行日 | 2015-12-08
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権利情報 | This document is the Accepted Manuscript version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.joc.5b02399.
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言語 |
eng
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著者版フラグ |
著者版
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部局 |
薬学系
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