ID 111896
Author
Komiya, Chiaki Tokushima University
Aihara, Keisuke Tokushima University
Morishita, Ko Tokushima University
Ding, Hao Tokushima University
Content Type
Journal Article
Description
A photo-responsive amide cleavage device was developed based on the asparagine imidation-mediated cleavage of peptide bonds during intein-mediated protein splicing. The chemical environment of the protein splicing process was mimicked by the incorporation of geminal dimethyl groups and a secondary amine unit in asparagine scaffold. Furthermore, the resulting photo-responsive device could induce the photo-triggered cleavage of an amide bond by the protection of the secondary amine unit with an o-nitrobenzyloxycarbonyl group.
Journal Title
The Journal of Organic Chemistry
ISSN
00223263
15206904
NCID
AA00704100
AA12097242
Publisher
ACS Publications
Volume
81
Issue
2
Start Page
699
End Page
707
Published Date
2015-12-08
Rights
This document is the Accepted Manuscript version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.joc.5b02399.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences