ID | 113348 |
Author |
Komiya, Chiaki
Tokushima University
Tsukimoto, Jun
Tokushima University
Ueda, Masahiro
Tokushima University
Morisaki, Takuya
Tokushima University
Inokuma, Tsubasa
Tokushima University
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Itoh, Kohji
Tokushima University
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Otaka, Akira
Tokushima University
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|
Content Type |
Journal Article
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Description | A traceless thioester-producing protocol featuring carboxypeptidase Y-mediated hydrazinolysis of cysteinyl prolyl leucine-tagged peptides has been developed. The hydrazinolysis followed by thioesterification affords cysteinyl prolyl thioesters. Self-editing of the tag and subsequent trans-thioesterification yields peptide thioesters. The developed protocol was successfully applied to conversion of recombinant proteins to thioesters.
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Journal Title |
Chemical Communications
|
ISSN | 13597345
1364548X
|
NCID | AA11071130
AA12455105
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Publisher | The Royal Society of Chemistry
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Volume | 55
|
Issue | 49
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Start Page | 7029
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End Page | 7032
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Published Date | 2019-05-23
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Rights | ©The Royal Society of Chemistry 2019
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Author
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departments |
Pharmaceutical Sciences
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