ID | 113348 |
著者 |
Komiya, Chiaki
Tokushima University
Tsukimoto, Jun
Tokushima University
Ueda, Masahiro
Tokushima University
Morisaki, Takuya
Tokushima University
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資料タイプ |
学術雑誌論文
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抄録 | A traceless thioester-producing protocol featuring carboxypeptidase Y-mediated hydrazinolysis of cysteinyl prolyl leucine-tagged peptides has been developed. The hydrazinolysis followed by thioesterification affords cysteinyl prolyl thioesters. Self-editing of the tag and subsequent trans-thioesterification yields peptide thioesters. The developed protocol was successfully applied to conversion of recombinant proteins to thioesters.
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掲載誌名 |
Chemical Communications
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ISSN | 13597345
1364548X
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cat書誌ID | AA11071130
AA12455105
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出版者 | The Royal Society of Chemistry
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巻 | 55
|
号 | 49
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開始ページ | 7029
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終了ページ | 7032
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発行日 | 2019-05-23
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権利情報 | ©The Royal Society of Chemistry 2019
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EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
著者版
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部局 |
薬学系
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