ID 106357
著者
Jambaldorj, Bayasgalan Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
テラダ, エリ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
ホサカ, トシオ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
キシュク, ユカ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
富岡, 有紀子 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧
イワシマ, カオリ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
ヒラタ, ヨウコ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
テシガワラ, キヨシ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Chung, Thi Kim Le Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
中川, 忠彦 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
原田, 永勝 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
酒井, 徹 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
阪上, 浩 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
松本, 俊夫 Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
船木, 真理 Clinical Research Center for Diabetes, Tokushima University Hospital 徳島大学 教育研究者総覧 KAKEN研究者をさがす
髙橋, 章 Department of Preventive Environment and Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
中屋, 豊 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
GLUT4
cysteine string protein 1
SNARE
VAMP2
資料タイプ
学術雑誌論文
抄録
Insulin stimulates glucose transporter 4 (GLUT4) vesicle recruitment from its intracellular storage site to the plasma membrane. Cysteine string protein 1 (CSP1) is a SNARE-binding protein involved in the vesicular trafficking of neurotransmitters and other exocytic processes. In this study, we investigated the involvement of CSP1 in insulin-dependent GLUT4 recruitment in 3T3-L1 adipocytes. Over-expression of wild-type CSP1 led to attenuated insulin-stimulated glucose uptake without any change in GLUT4 content in the plasma membrane, rather it inhibits docking by blocking the association of VAMP2 with syntaxin 4. In contrast, knockdown of CSP1 enhanced insulin-stimulated glucose uptake. The mRNA and protein expression of CSP1 was elevated in 3T3-L1 adipocytes in insulin resistant states caused by high levels of palmitate and chronic insulin exposure. Taken together, the results of this study suggest that CSP1 is involved in insulin resistance by interrupting GLUT4 vesicle docking with the plasma membrane.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
3-4
開始ページ
197
終了ページ
204
並び順
197
発行日
2013-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院
先端酵素学研究所