ID 109844
タイトルヨミ
サイボウ フカツ コウカ オ ネラッタ チタン ヒョウメン ショリホウ
タイトル別表記
Development of Titanium Surface Treatment for Promoting Cell-activation
著者
関根, 一光 徳島大学大学院ヘルスバイオサイエンス研究部生体材料工学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
titanium materials
functional materials
surface modification
neointima
資料タイプ
学術雑誌論文
抄録
Thromboembolism events around the cannula and cardiac periventricular were oftenly reported after implanting ventricular assist devices. To assist preventing these problems, we have studied the surface structural modification, based on the titanium (Ti) micro-porous structure, the chemical modification, and the hydro-oxidization treatment. The purpose of this study is the fabrication and evaluation of their fundamental modification that would be the factor of the neointimal growth in vivo.
Titanium powder was mixed with melted thermoplastic wax as the plastic compound method, and with calcium phosphate paste as the ceramics compound method. From each paste, adequate specimens were manufactured after sintering. Specimens were measured the porosity and the pore size, and were also evaluated in several mechanical properties. Compared to two methods for manufacturing the Ti micro-porous materials, the plastic compounds showed the fine characteristics in mechanical properties. But for applying as the scaffold for neointimal and blood compatible materials, these specimens would be better for promoting the blood vessel neointima.
For the chemical modification of Ti materials surface, bulk Ti specimens were operated with the hydroxide treatment for modification. For promoting the cell growth, type I collagen were put on as the amino group rich container, and fixed with isocyanate for deriving the urethane bonding on the surface. After these treatments, specimens were measured their fixed collagen. Specimens were also observed by SEM, and analyzed by X-ray photoelectron spectroscopy. Fibroblast cells were also harvested on specimens’ surface for studying the performances as the scaffold. Our hydroxide treatment showed the favorable performance for the stability of hydroxyl gel surface and modified collagen, and also indicated as the fine scaffold.
Our results indicated the possibility of application for perivascular position and blood contacting situation, by promoting the cell-activation depending on micro-porous structure and modified titanium surface. Especially by choosing and trying the adequate cell activating factor concerning among the multiple organs and implantable devices, these treatment would be widely applicable for them.
掲載誌名
四国歯学会雑誌
ISSN
09146091
cat書誌ID
AN10050046
出版者
四国歯学会
26
2
開始ページ
49
終了ページ
54
並び順
49
発行日
2014-02-14
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系