ID 110172
著者
イシカワ, ミズキ Graduate School of Integrated Arts and Sciences, Tokushima University
ムラグチ, リョウスケ Graduate School of Integrated Arts and Sciences, Tokushima University
アズマ, アヤコ Graduate School of Integrated Arts and Sciences, Tokushima University
ナワタ, ショウゴ Graduate School of Integrated Arts and Sciences, Tokushima University
ミヤ, ムツミ Graduate School of Integrated Arts and Sciences, Tokushima University
カツウラ, テツヤ Graduate School of Integrated Arts and Sciences, Tokushima University
内藤, 徹 Graduate School of Integrated Arts and Sciences, Tokushima University
小山, 保夫 Graduate School of Integrated Arts and Sciences, Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
資料タイプ
学術雑誌論文
抄録
2,2-Dibromo-3-nitrilopropionamide (DBNPA) is a major biocide in hydraulic fracturing fluids. Most biocides in fracturing fluids are considered to have low acute toxicity to mammals, but little information is available in the literature regarding the toxic actions of DBNPA on mammalian cells. This information is important to suggest the DBNPA toxicity on wild mammals. In this study, the effects of DBNPA on rat thymocytes were studied using flow cytometric techniques in order to further characterize the cytotoxicity of DBNPA for its safe use. DBNPA at 3-7.5 μM produced a steep concentration-dependent increase in cell lethality. At 5 μM, DBNPA significantly depolarized membranes with disturbance of asymmetrical distribution of membrane phospholipids. The lethal effect of DBNPA was completely abolished under cold conditions, and was augmented in the presence of ethanol. It is suggested that the lethal action of DBNPA is linked to changes in membrane fluidity. Because the concentration-dependent change of DBNPA-induced lethal action was very steep under in vitro conditions, the adverse actions of DBNPA on wild mammals are concerning, even though such reports have not yet surfaced.
掲載誌名
Toxicology Research
ISSN
20454538
2016
5
開始ページ
1329
終了ページ
1334
並び順
1329
発行日
2016-06-21
備考
This journal is Copyright © The Royal Society of Chemistry 2016
EDB ID
319213
出典
Toxicology Research (2016) Issue 5 p.1329-1334
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
生物資源系