直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 110702
著者
Sun, Xue-Zhi Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Zhang, Rui Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Cui, Chun Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
タカハシ, センタロウ Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
クボタ, ヨシヒサ Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
澤田, 和彦 Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
福井, 義浩 Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
cell adhesion molecular
irradiation
migration
neocortex
資料タイプ
学術雑誌論文
抄録
To gain insight to the cellular and molecular mechanisms involved abnormal neuronal migration induced by irradiation, we investigated expression of neuronal cell adhesion molecule L 1 and neuronal migration in the brains through comparison between rats prenatally exposed to X-ray and controls. To observe the pattern of neuronal migration, bromodeoxyuridine (BrdU) was chosen as a marker to label migrating cells. The results showed some of the labeled cells remained in the lower of the cortical plate in the irradiated rats, suggesting that neuronal migration was disrupted by X-ray. To study change of expressing neural cell molecule L1, rat brains were analyzed by SDS-PAGE after isolation of L1 by immunoaffinity chromatography. In the all brain membrane fraction, immunoaffinity purified L1 had bands at 200, 180, 140 and 80 kDa. However, the bands in the irradiated group were very weak when compared with the control. Taking these results into account, abnormal neuronal migration and reduction of expression L1 found in their radiated brain indicated that migration of neural cells may be largely dependent on radial glial fiber as well as neural cell molecules like L1. A decrease in L1 expressionmay be one of reasons of abnormal neuronal migration.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
50
3-4
開始ページ
187
終了ページ
191
並び順
187
発行日
2003
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系