ID 110796
著者
キノシタ, ケイゴ Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima, Graduate School|Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
新家, 利一 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima, Graduate School
佐藤, 陽一 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima, Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
クラハシ, ヒロキ Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University
コウワ, ヒロエ Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University
Chen, Gang Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima, Graduate School
梅野, 真由美 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima, Graduate School
樋田, 一徳 Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School
キヨカゲ, エミ Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School
ナカノ, タクロウ Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima, Graduate School
伊東, 進 Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧
中堀, 豊 Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima, Graduate School
キーワード
HSFY
mHSFYL
HSF
Y chromosome
spermatogenesis
資料タイプ
学術雑誌論文
抄録
Heat shock transcription factor on Y (HSFY) is located in one of three candidate regions for azoospermic factor (AZF), AZFb on the Y chromosome. We and others have already revealed that some azoospermic males are missing the regions of the Y chromosome including HSFY. Previously, we showed that murine HSFY-like sequence〔mHSFYL(RikencDNA4933413G11Rik)〕, which is the mouse orthologue of HSFY, is exclusively expressed in testis. The sequences encoding the presumed DNA-binding domain in HSFY and mHSFYL were found in other mammals such as dogs, cows and chickens. To elucidate mHSFYL expression in the testes in detail, we carried out in situ hybridization. mHSFYL was predominantly expressed in round spermatids. Furthermore, we clarified the intracellular distribution of mHSFYL inCOS1 cells with HA- or GFP-tagged proteins. Both HA-mHSFYL and GFP-mHSFYL were located in the nucleus. Our results suggest that HSFY/mHSFYL may have evolutionarily conserved functions for spermatogenesis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
1-2
開始ページ
117
終了ページ
122
並び順
117
発行日
2006-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
医学系