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ダウンロード数 : ?
ID 110826
著者
上野, 明道 Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School
山下, 菊治 Department of Oral and Maxillofacial Anatomy, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
三好, 圭子 Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
堀口, 大吾 Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Ruspita, Intan Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School
阿部, 佳織 Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
野間, 隆文 Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
dental pulp cells
osteoblast
extracellular matrix
mineralization
資料タイプ
学術雑誌論文
抄録
Dental pulp cells have a capacity to differentiate into mineralization-inducing cells. To clarify the molecular mechanism, we established an in vitro mineralization-inducing system by rat clonal dental pulp cell line, RPC-C2A, and tried to purify a mineralizationinducing factor in conditioned medium (CM) from preosteoblastic MC3T3-E1 cells. The active factor was impermeable to an ultrafiltrating membrane, and sedimented by ultracentrifugation. The sedimented factor was found as a needle-like structure about 1.3 μm in average length as observed by transmission electron microscopy. The factor contained type I collagen, suggesting not a matrix vesicle, but a soluble matrix. The mineralizationinducing activity was also detected in CM from primary culture of rat calvaria (RC) cells. These results suggested that the soluble matrices from osteoblastic cells serve, at least in part, as differentiation-inducing agents.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
3-4
開始ページ
297
終了ページ
302
並び順
297
発行日
2006-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
病院