ID 110860
著者
Jung, Eun Ju Departments of Dermatology, Institute of Health Biosciences, the University of Tokushima Graduate School
河合, 智子 Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School
Park, Hwan Ki Division of Enzyme Pathophysiology, The Institute for Enzyme Research, the University of Tokushima
久保, 宜明 Departments of Dermatology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
六反, 一仁 Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
荒瀬, 誠治 Departments of Dermatology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
ultraviolet B irradiation
skin damage
peripheral blood cells
gene expression
marker genes
資料タイプ
学術雑誌論文
抄録
Ultraviolet B (UVB) is a serious irritant for the skin and increases a risk for skin cancer. To identify UVB-sensitive genes in peripheral blood, 11 healthy male volunteers were exposed to 0.3 J/cm2 of narrow-band (NB)-UVB, about half of minimal erythema dose (MED) in Japanese, and gene expression in blood was analyzed at 4 h, 24 h, 4 d and 7 d after the irradiation using microarray carrying oligonucleotide probes for 2,000 stressresponsive genes. RNA prepared before the irradiation was used as a reference control. Microarray analysis identified 21 genes as UVB-responsive genes with a peak at 24 h in 6 subjects, and real-time PCR validated the significant down-regulation of 9 (ABCB10, ATF1, ABCD3, TANK, FAS, SLC30A9, CHUK, CASP1, and ABCE1) out of the 21 genes in 11 subjects. Considering sensitive and characteristic features of 9 marker genes, they may be useful indicators for monitoring systemic response to UVB irradiation.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
3-4
開始ページ
204
終了ページ
210
並び順
204
発行日
2008-08
EDB ID
191596
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系